APPLICATION NOTE

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TLA Technology & targeted complete NGS sequencing

The original TLA protocol (Nature Biotechnology 2014) requires cells as input material. This application note describes the features and applications of the TLA protocol for isolated human genomic DNA.

Highlights

Cergentis’ TLA technology:

  • enables targeted complete gene sequencing.
  • requires one primer pair complementary to a short locus specific sequence.
  • detects all single nucleotide variants and structural variants.
  • enables haplotyping.
  • is easy to execute with standard laboratory equipment.

 

Application note - Features and applications of the human genomic DNA TLA protocol

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